Tumour immunology

Tumour immunology: T cells work together to fight cancer

A central question in tumour immunology is whether a tumour-specific immune response is capable of controlling tumour progression in cancer patients. Although several animal models have established the role of tumour-specific CD4+ helper and CD8+ cytotoxic T cells in antitumour immunity, a definitive role for these cells in tumour-specific immunity in patients with cancer has yet to be shown. I...

Tumour radiobiology beyond fractionation

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

Anti-tumour activity and store operated calcium entry: new roles in immunology

» A few of the mechanisms in which cytotoxic T cells work against tumour cells is through the expression of FasL, release of cytolytic granules and secretion of cytokines such as IFNg and TNFa, which induce apoptosis of cancer cells. These processes are dependent on intracellular Ca2þ signals... « Ca2þ signalling plays a critical role in almost every cell type of the immune system—T cells, B ce...

A Perturbation Problem Arising from the Modelling of Soluble Fas Ligand in Tumour Immunology

h has been known for many years that immune cells can kill cancer cells by a variety of mechanisms. However, new experimental evidence suggests that cancer cells also express these cell killing mechanisms. This enables the tumour to mount a counterattack against the anticancer immune cells. Baaed on these observations. we propose an ordinary differential equation model for tumour-immune cell in...

Immunology